An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15895 entries, 13848 authors and 1929 subjects. Updated: June 2, 2023

LAPOINTE, Janice W.

1 entries
  • 13950

Nucleosomes inhibit the initiation of transcription but allow chain elongation with the displacement of histones.

Cell, 49, 203-210, 1987.

Within the nucleosome Kornberg found that roughly 200 bp of DNA are wrapped around an octamer of histone proteins. With Yahli Lorch, Kornberg showed that a nucleosome on a promoter prevents the initiation of transcription, leading to the recognition of a functional role for the nucleosome, which serves as a general gene repressor. Order of authorship in the original publication: Lorsch, Lapointe, Kornberg.



Subjects: BIOLOGY › Cell Biology, BIOLOGY › MOLECULAR BIOLOGY