An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15875 entries, 13820 authors and 1929 subjects. Updated: March 30, 2023


1 entries
  • 11876

A bacteriophage nucleus like compartment shields DNA from CRISPR nucleases.

Nature, 577, 244-248, 2020.

Order of authorship in the original publication: Mendoza, Nieweglowska, Govindarajan. The authors showed that the large phage that specifically infects a Pseudomonas bacterium segregates its DNA, which the phage CRISPR would attack and destroy, by building a proteinaceous compartment or wall around its DNA. This protein barrier makes its DNA inaccessible to the CRISPR nuclease attack and destruction. This could be called the operation of natural selection at the molecular level.

(Thanks to Juan Weiss for this reference and its interpretation.)

Subjects: BIOLOGY › MOLECULAR BIOLOGY › CRISPR , VIROLOGY › Bacteriophage, WOMEN, Publications by › Years 2000 -