An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16077 entries, 14165 authors and 1948 subjects. Updated: May 6, 2025

Permanent Link for Entry #12981

  • 10785

Enzymatic amplication of B-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.

Science, 230, 1350-1354, 1985.

Polymerase chain reaction first published. With Randall K. Saiki, Stephen Scharf, Fred Faloona et al. Order of authorship in the original paper was Saiki, Scharf, Faloona, Mullis....

In 1993 the Nobel Prize in Chemistry 1993 was awarded "for contributions to the developments of methods within DNA-based chemistry." Mullis received half "for his invention of the polymerase chain reaction (PCR) method," and the other half was awarded to Michael Smith "for his fundamental contributions to the establishment of oligonucleotide-based, site-directed mutagenesis and its development for protein studies."

See also No. 7213.

(Thanks to Juan Weiss for this reference.)



Subjects: BIOLOGY › MOLECULAR BIOLOGY › Polymerase Chain Reaction, GENETICS / HEREDITY › HEREDITARY / CONGENITAL DISEASES OR DISORDERS › Blood Disorders › Sickle-Cell Disease, NOBEL PRIZES › Nobel Prize in Chemistry (selected)
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