An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”
Permanent Link for Entry #14053
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The new frontier of genome engineering with CRISPR-Cas9.Science, 346. DOI: 10.1126/science.1258096, 2014.Order of authorship in the original paper: Doubna, Charpenter. "Abstract "The advent of facile genome engineering using the bacterial RNA-guided CRISPR-Cas9 system in animals and plants is transforming biology. We review the history of CRISPR (clustered regularly interspaced palindromic repeat) biology from its initial discovery through the elucidation of the CRISPR-Cas9 enzyme mechanism, which has set the stage for remarkable developments using this technology to modify, regulate, or mark genomic loci in a wide variety of cells and organisms from all three domains of life. These results highlight a new era in which genomic manipulation is no longer a bottleneck to experiments, paving the way toward fundamental discoveries in biology, with applications in all branches of biotechnology, as well as strategies for human therapeutics." (Thanks to Juan Weiss for this reference and its interpretation.) Subjects: BIOLOGY › MOLECULAR BIOLOGY › CRISPR Gene Editing Permalink: www.historyofmedicine.com/id/14053 |