Owen’s first large-scale original work covered the whole range of the toothed vertebrates, living and fossil, and discussed in detail the micrsocopic structure of the teeth and the physiology of dentition. Includes 168 plates. His comprehensive investigation of the morphology of mammalian teeth led him into palaeontology, of which he soon became one of the masters. Owen, son-in-law of William Clift, was from 1836-56 Hunterian professor at the Royal College of Surgeons. During the 1860s he was one of the most virulent opponents of Darwinism. Some copies of this work were issued on large paper.