This paper proposed two general principles: 1) The Sequence Hypothesis: “The order of bases in a portion of DNA represents a code for the amino acid sequence of a specific protein. Each ‘word’ in the code would name a specific amino acid. From the two dimensional genetic text, written in DNA, are forced the whole diversity of uniquely shaped three-dimensional proteins” , and 2) The Central Dogma: “Information is transmitted from DNA and RNA to proteins, but information cannot flow from a protein to DNA. This paper “permanently altered the logic of biology” (Judson).
Crick's first published statement of The Central Dogma appeared in the September 1957 issue of Scientific American, 197, No. 3, 188-203, based upon his famous "Central Dogma" lecture given in September 1957 (G-M 13097).