TEMIN, Howard Martin
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RNA-dependent DNA polymerase in virions of Rous sarcoma virus.Nature (Lond.), 226, 1211-13, 1970.Discovery of reverse transcriptase. "In 1969, Temin and a postdoctoral fellow, Satoshi Mizutani, began searching for the enzyme that was responsible for the phenomenon of viral RNA being transferred into proviral DNA.[5] Later that year, Temin showed that certain tumor viruses carried the enzymatic ability to reverse the flow of information from RNA back to DNA using reverse transcriptase. Reverse transcriptase was also independently and simultaneously discovered in association with the murine leukemia virus by David Baltimore at the Massachusetts Institute of Technology.[10] In 1975, Baltimore and Temin shared the Nobel Prize of Physiology or Medicine.[11] Both scientists completed their initial work with RNA-dependent DNA polymerase with the Rous sarcoma virus." (Wikipedia article on Howard Martin Temin, accessed 3-2020). Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Synthesis, ONCOLOGY & CANCER, VIROLOGY › Molecular Virology, VIROLOGY › VIRUSES (by Family) › Retroviridae › Rous Sarcoma Virus (RSV) |
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RNA-dependent DNA polymerase virions of Rous sarcoma virus.Nature, 226, 1211-1213, 1970.For his discovery of reverse transcriptase, in 1975 Temin shared the 1975 Nobel Prize with Renato Dulbecco and David Baltimore. Subjects: BIOLOGY › MOLECULAR BIOLOGY, ONCOLOGY & CANCER, VIROLOGY › VIRUSES (by Family) › Retroviridae › Rous Sarcoma Virus (RSV) |