An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15959 entries, 13943 authors and 1935 subjects. Updated: March 1, 2024

SHATKIN, Aaron J.

1 entries
  • 13976

Reovirus messenger RNA contains a methylated, blocked 5'-terminal structure: m7G(5')ppp(5')GmpCp.

Proc. Nat. Acad. Sci. (USA), 72, 362-366, 1976.

Furuichi, working in Shatkin's laboratory, discovered that the viral mRNAs synthesized in vitro by the virion-associated RNA polymerase of reovirus contain a unique 5′-terminal structure m7GpppNm or cap. The precise biosynthetic pathways leading to the cap formation were then elucidated. These and other breakthroughs eventually led to the finding that this unique cap structure is also present in both the eukaryotic cytoplasmic mRNAs and heterogeneous nuclear RNAs, which in turn led to the discovery of mRNA splicing, critical to mRNA vaccines.  With M. Morgan and S. Muthukrishnan.

Digital facsimile from PubMedCentral at this link.



Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Synthesis, IMMUNOLOGY › Vaccines