An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

SØRENSON, Anne L.

1 entries
  • 11997

Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis.

Infection and Immunity, 63, 1710-1717, 1995.

Andersen and colleagues found that a protein fraction obtained from M. tuberculosis was immunologically active in mice, suggesting that it was one of the proteins recognized by T cells. In this paper the authors identified and purified the active protein, ESAT-6, and showed that it consists of 95 amino acids. This work and that of Mahairas and colleagues (No. 11995) led to a new test called the Interferon gamma release assay.

(Thanks to Ron Cox for this reference and its interpretation.)



Subjects: BACTERIOLOGY › BACTERIA (mostly pathogenic; sometimes indexed only to genus) › Gram-Positive Bacteria › Mycobacterium › Mycobacterium tuberculosis, IMMUNOLOGY › Immunization, INFECTIOUS DISEASE › Tuberculosis