An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16018 entries, 14076 authors and 1941 subjects. Updated: July 14, 2024

DEVREE, Brian T.

1 entries
  • 14134

Crystal structure of the β2 adrenergic receptor–Gs protein complex.

Nature, 477, 549-555, 2011.

Kobilka and colleagues published the crystal structure of a beta-2 receptor forming a complex with the G protein coupled receptor. This was the first time that a complete complex of an active receptor and it's Gs protein partner were crystallized.They also described some’of the basic molecular interactions of a beta receptor and G protein coupled receptors. The image of this crystallographic complex that they published was described by more romantic molecular biologists as “the first image of the receptor locked in an embrace with its protein partner.” Order of authorship in the original publication: Rasmussen, Devree....Kobilka.

In 2012 Kobilka shared the Nobel Prize in Chemistry with Robert J. Lefkowitz "for studies of G-protein-coupled receptors."

See also No. 14135.

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Receptors, NOBEL PRIZES › Nobel Prize in Chemistry