RICE, Charles Moen
Science, 277, 570-74, 1997.
Rice (Nobel Prize 2020) and colleagues constructed a viral RNA genome with the 3’ region and a consensus region to exclude potential inactivating mutations, which was then injected into the liver of chimps. That RNA, specifically encoded for the Hepatitis C virus (HVC), established a productive infection, and a clinical hepatitis resulted. Infectious virus was found in chimps' blood for several months from this "non mutation prone and ultrapure" RNA genome, which coded bonafide virus and also provoked the specifically expected antibody response.
Order of authorship in the original publication: Kolyphalov, Agapov..., Rice.
Subjects: VIROLOGY › VIRUSES (by Family) › Hepadnaviridae › Hepatitis C Virus