MASTERS, Colin Louis
The spectrum of Creutzfeldt-Jakob disease and the virus-induced subacute spongiform encephalopathies. IN: Smith & Cavanagh, editors, Recent advances in neuropathology, Vol. 2., Chapter 6, pp. 129-163.Edinburgh: Churchill-Livingstone, 1982.
The authors reported a detailed and complete analysis of the original slides of the brain done by Afons Jakob, and provided a partial translation into English, with a detailed analysis of Jakob's clinical description, of the four cases he reported in his paper of 1921, and his fifth case reported in 1923. They concluded, "In summary our review of the original sections used by Jakob establishes several important points which help in the clarification of the nosology of CJD. First, at least two of Jakob's five cases had spogiform encephalopathy which fall within the present day diagnostic criteria. These cases represent the earliest proven examples of subacute spongiform encephalopathy, and justify the retention of Jakob's name in the eponymous designation of the disease." They also stated that "...Creutzfeldt's case remains undiagnosed by modern criteria, but fit best within the acquired toxic-metabolic encephalopathies." Their findings confirmed that Jakob, and not Creutzfeldt, first described what came to be known, incorrectly, as Creutzfeldt-Jakob disease.
Subjects: INFECTIOUS DISEASE › Prion Diseases, NEUROLOGY › Degenerative Disorders