An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

MASTERS, Colin Louis

1 entries
  • 12595

The spectrum of Creutzfeldt-Jakob disease and the virus-induced subacute spongiform encephalopathies. IN: Smith & Cavanagh, editors, Recent advances in neuropathology, Vol. 2., Chapter 6, pp. 129-163.

Edinburgh: Churchill-Livingstone, 1982.

The authors reported a detailed and complete analysis of the original slides of the brain done by Afons Jakob, and provided a partial translation into English, with a detailed analysis of Jakob's clinical description, of the four cases he reported in his paper of 1921, and his fifth case reported in 1923. They concluded, "In summary our review of the original sections used by Jakob establishes several important points which help in the clarification of the nosology of CJD. First, at least two of Jakob's five cases had spogiform encephalopathy which fall within the present day diagnostic criteria. These cases represent the earliest proven examples of subacute spongiform encephalopathy, and justify the retention of Jakob's name in the eponymous designation of the disease." They also stated that "...Creutzfeldt's case remains undiagnosed by modern criteria, but fit best within the acquired toxic-metabolic encephalopathies." Their findings confirmed that Jakob, and not Creutzfeldt, first described what came to be known, incorrectly, as Creutzfeldt-Jakob disease. 

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: INFECTIOUS DISEASE › Prion Diseases, NEUROLOGY › Degenerative Disorders