Cell, 37, 179-183, 1984.
Solter discovered mammalian genomic imprinting that causes parent-of-origin specific gene expression, with consequences for development and disease.
"Genomic imprinting is an epigenetic phenomenon that causes genes to be expressed or not, depending on whether they are inherited from the mother or the father. Genes can also be partially imprinted. Partial imprinting occurs when alleles from both parents are differently expressed rather than complete expression and complete suppression of one parent's allele. Forms of genomic imprinting have been demonstrated in fungi, plants and animals. ...
"Appropriate imprinting of certain genes is important for normal development. Human diseases involving genomic imprinting include Angelman syndrome, Prader–Willi syndrome and male infertility. (Wikipedia article Genomic imprinting, accessed 7-22).
Subjects: BIOLOGY › MOLECULAR BIOLOGY › Genomics, EMBRYOLOGY