An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15951 entries, 13922 authors and 1934 subjects. Updated: November 30, 2023


1 entries
  • 13991

Completion of mouse embryogenesis requires both the maternal and paternal genomes.

Cell, 37, 179-183, 1984.

Solter discovered mammalian genomic imprinting that causes parent-of-origin specific gene expression, with consequences for development and disease.

"Genomic imprinting is an epigenetic phenomenon that causes genes to be expressed or not, depending on whether they are inherited from the mother or the father. Genes can also be partially imprinted. Partial imprinting occurs when alleles from both parents are differently expressed rather than complete expression and complete suppression of one parent's allele. Forms of genomic imprinting have been demonstrated in fungi, plants and animals. ...
Genomic imprinting is an inheritance process independent of the classical Mendelian inheritance. It is an epigenetic process that involves DNA methylation and histone methylation without altering the genetic sequence. These epigenetic marks are established ("imprinted") in the germline (sperm or egg cells) of the parents and are maintained through mitotic cell divisions in the somatic cells of an organism.

"Appropriate imprinting of certain genes is important for normal development. Human diseases involving genomic imprinting include Angelman syndromePrader–Willi syndrome and male infertility. (Wikipedia article Genomic imprinting, accessed 7-22).