An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

LOEFFLER, Friedrich August Johann

5 entries
  • 5056

Untersuchungen über die Bedeutung der Mikroorganismen für die Entstehung der Diphtherie beim Menschen, bei der Taube und beim Kalbe.

K. Ges. -Amt., 2, 421-99, 1884.

Loeffler succeeded in cultivating C. diphtheriae, the diphtheria bacillus. He reproduced the characteristic membrane by swabbing the mucous membranes of various animals with pure cultures of the bacillus.
In this paper Loeffler, who was working as one of Koch's assistants, stated on p. 424 three postulates similar to Koch's 4 postulates:
1. The organisms must be shown to be constantly present in characteristic form and arrangement in the diseased tissue.
2. The organisms which, from their behavior appear to be responsible for the disease, must be isolated and cultivated in purity.
3. The pure cultures must be shown to induce disease experimentally.

D. Jay Grimes, "Koch's postulates- then and now," Microbe 1 (2006) 223-228.

Subjects: BACTERIOLOGY › BACTERIA (mostly pathogenic; sometimes indexed only to genus) › Gram-Positive Bacteria › Corynebacterium diphtheriae, INFECTIOUS DISEASE › Diphtheria, INFECTIOUS DISEASE › GENERAL PRINCIPLES of Infection by Microorganisms
  • 5156

Die Aetiologie der Rotzkrankheit.

Arb. k. GesundhAmte, 1, 141-98, 1886.

Discovery of Burkholderia mallei, causative organism of glanders. Preliminary notice in Dtsch. med. Wschr., 1882, 8, 707.

Subjects: BACTERIOLOGY › BACTERIA (mostly pathogenic; sometimes indexed only to genus) › Gram-Negative Bacteria › Burkholderia mallei, INFECTIOUS DISEASE › Glanders, VETERINARY MEDICINE
  • 2579

Vorlesungen über die geschichtliche Entwickelung der Lehre von den Bacterien. Teil l.[All published].

Leipzig: F. C. W. Vogel, 1887.

Loeffler, Professor of Hygiene at Greifswald, made many discoveries in bacteriology. His history of the subject was the first and only history of bacteriology prior to the publication of Bulloch's History of bacteriology (1938). It was unfortunately left unfinished. Digital facsimile from Biodiversity Heritage Library at this link.

Subjects: BACTERIOLOGY › History of Bacteriology
  • 2507

Ueber Epidemieen unter den im hygienischen Institute zu Greifswald gehaltenen Mäusen und über die Bekämpfung der Feldmausplage.

Zbl. Bakt., 11, 129-41, 1892.

Isolation of Salm. typhi-murium.

Subjects: BACTERIOLOGY › BACTERIA (mostly pathogenic; sometimes indexed only to genus) › Gram-Negative Bacteria › Salmonella, INFECTIOUS DISEASE › Salmonellosis › Typhoid Fever
  • 2511

Bericht der Kommission zur Erforschung der Maul-und Klauenseuche bei dem Institut für Infektionskrankheiten.

Zbl. Bakt., I. Abt., 23, 371-91, 1898.

Loeffler and Frosch proved that foot-and-mouth disease is caused by a filter-passing virus; this was the first recognition that a virus causes disease. 

Subjects: VETERINARY MEDICINE › Veterinary Virology, VIROLOGY