An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15872 entries, 13813 authors and 1928 subjects. Updated: March 23, 2023

MARTIN, Gail Roberta

1 entries
  • 13961

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells (embryonic stem cells/inner cell masses/differentiation in vitro/embryonal carcinoma cells/growth factors) .

Proc. Nat. Acad. Sci. (USA), 78, 7634-7638, 1981.

Martin used a different approach that avoided in vivo alteration. She reasoned that an ES cell line might be obtained by culturing cells isolated from blastocysts in a medium that had previously been conditioned by an established teratocarcinoma stem-cell line (such a medium might contain a factor that stimulates ES-cell proliferation and/or suppress their differentiation). Using this approach, she established a cell line directly from normal pre-implantation mouse embryos and confirmed its pluripotency by showing that individual cells of this line could differentiate to form a wide variety of cell types in vitro and in vivo.  Digital facsimile from PubMedCentral at this link.

Subjects: BIOLOGY › Developmental Biology, Regenerative Medicine