Suppression of RNA recognition by toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA.Immunity, 23, 165-175, 2005.
Karikó and Weissman discovered the nucleoside modifications that suppress the immungenicity of RNA, leading to their patents for the application of non-immunogenic, nucleoside-modified RNA (modRNA). This technology was licensed by Pfizer BioNTech and Moderna to develop their mRNA COVID-19 vaccines. Order of authorship in the original publication: Karikó, Buckstein, Ni, Weissman.
Subjects: BIOLOGY › MOLECULAR BIOLOGY, IMMUNOLOGY › Immunization, IMMUNOLOGY › Molecular Immunology, IMMUNOLOGY › Vaccines, VIROLOGY › VIRUSES (by Family) › Coronaviruses (Coronaviridae) › SARS CoV-2 (Cause of COVID-19)