A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions,Proc. Nat. Acad. Sci. (USA), 80, 3812-3815, 1983.
Zur Hausen and colleageus identified HPV 16 DNA in cervical cancer tumors by Southern blot hybridization.
Digital facsimile from PubMedCentral at this link.
Subjects: ONCOLOGY & CANCER › Carcinoma, VIROLOGY › VIRUSES (by Family) › Papillomaviridae, VIROLOGY › VIRUSES (by Family) › Papillomaviridae › Human Papillomavirus (HPV)
A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer.EMBO J., 3, 1151-1157, 1984.
Zur Hausen and colleagues discovered HPV18 as a cause of cervical cancer. With the discovery of HPV18, and HPV16, which zur Hausen and team discovered in 1983, zur Hausen discovered the viruses causing about 75% of human cervical cancer, and provided a basis on which other researchers could develop a vaccine against cervical cancer. (Order of authorship in the original publication: Boshart, Gissmann, Ikenberg, Kleinheinz, Scheurlen, zur Hausen.) Digital facsimile from PubMedCentral at this link.
"Harald zur Hausen went against current dogma and postulated that oncogenic human papilloma virus (HPV) caused cervical cancer. He realized that HPV-DNA could exist in a non-productive state in the tumours, and should be detectable by specific searches for viral DNA. He and others, notably workers at the Pasteur Institute, found HPV to be a heterogeneous family of viruses. Only some HPV types cause cancer.
"Harald zur Hausen pursued his idea of HPV for over 10 years by searching for different HPV types.  This research was difficult due to the fact that only parts of the viral DNA were integrated into the host genome. He found novel HPV-DNA in cervix cancer biopsies, and thus discovered the new, tumourigenic HPV16 type in 1983. In 1984, he cloned HPV16 and 18 from patients with cervical cancer. The HPV types 16 and 18 were consistently found in about 70% of cervical cancer biopsies throughout the world.
"His observation of HPV oncogenic potential in human malignancy provided impetus within the research community to characterize the natural history of HPV infection, and to develop a better understanding of mechanisms of HPV-induced carcinogenesis. (Wikipedia article HPV vaccine, accessed 5-2020).
Subjects: ONCOLOGY & CANCER › Carcinoma, VIROLOGY › VIRUSES (by Family) › Papillomaviridae › Human Papillomavirus (HPV)