By selective breeding over a period of 15 years, Slye produced generations of mice absolutely resistant to, or particularly susceptible to, cancer. She demonstrated that resistance is a Mendelian dominant and susceptibility a recessive, either of which can be bred into or out of susceptible or resistant generations, according to the laws of genetics. Her earlier papers are in J. med. Res., 1914, 25, 281; 1915, 27, 159; J Cancer Res., 1916, 1, 479, 503; 1921, 6, 139; 1922, 7, 107.