Biochemical method for inserting new genetic information into DNA of simian virus 40: Circular SV40 DNA molecules containing Lambda phage genes and the galactose operon of Escherichia coli.Proc. Nat. Acad. Sci. (U.S.A.), 69, 2904-2909, 1972.
First recombinant DNA molecules generated. Digital facsimile from PubMedCentral at this link.
Subjects: BIOLOGY › MOLECULAR BIOLOGY › Recombinant DNA
Science, 209, 1422-1427, 1980.
(Order of authorship in the original publication: Mulligan, Berg.) In an understated paper the authors suggested the potential of treating recessive diseases like Lesch-Nyhan syndrome by gene therapy.
Subjects: BIOLOGY › MOLECULAR BIOLOGY, GENETICS / HEREDITY › GENETIC DISORDERS, GENETICS / HEREDITY › Gene Therapy / Human Gene Transfer