An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15872 entries, 13813 authors and 1928 subjects. Updated: March 23, 2023

DENIS, Prosper Sylvain

2 entries
  • 13909

Recherches expérimentales sur le sang human considérè à l'état sain.

Paris: Chez les libraires qui tiennent les ouvrages de médecine, 1830.

Denis discovered the presence of cholesterol (“cholestérine”) in the blood. This he announced on p. 110 of his Recherches expérimentales.

Subjects: HEMATOLOGY, Laboratory Medicine › Blood Tests
  • 12874

Mémoire sur le sang quand il est fluide, pendant qu’il se coagule et lorsqu’il est coagulé.

Paris: J.-B. Baillière, 1859.

The first attempt to isolate and describe fibrinogen, the blood protein essential for clotting. “Prosper-Sylvain Denis, in his Mémoire sur le sang (1859), was the first to recognize that plasma contained a clottable substance, not defined as a liquid fibrin, but different from fibrin, and he attempted to purify and characterize this protein. He independently proposed the name fibrinogène” (Rosenfeld, Four Centuries of Clinical Chemistry, p. 438).

Subjects: HEMATOLOGY › Coagulation