GADDUM, Sir John Henry
The action of adrenalin and ergotamine on the uterus of the rabbit.J. Physiol. (Lond.), 61, 141-50, 1926.
Gaddum produced concentration-effect curves of antagonistic drugs, showing the dose-ratio linearly related to antagonistic concentration. See also No. 1925.1
Subjects: PHARMACOLOGY, PHARMACOLOGY › Pharmacodynamics
The chemical transmitter at synapses in a sympathetic ganglion.J. Physiol. (Lond.), 81, 305-19, 1934.
These workers produced evidence that a chemical agent (acetylcholine) appears in the transfer of nerve impulses from neuron to neuron in sympathetic ganglia.
Subjects: NEUROSCIENCE › NERVOUS SYSTEM › Chemical Mediation of Nervous Impulses
The quantitative effect of antagonistic drugsJ. Physiol. (Lond.), 89, 7P-9P, 1937.
Gaddum was the first to formulate the theory of competitive drug antagonism. See also No. 1917.
Subjects: PHARMACOLOGY › Pharmacodynamics