An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

SPIEGELMAN, Sol

1 entries
  • 13992

The synthesis of a self-propagating and infectious nucleic acid with a purified enzyme.

Proc. Nat. Acad. Sci. (USA) 54, 919-927, 1965.
Spiegelman's Monster, the name given to an RNA chain of only 218 nucleotides that can be reproduced by the RNA replication enzyme RNA-dependent RNA polymerase, also called RNA replicase. Spiegelman achieved the first synthesis of a biologically competent, infective viral nucleic acid. See https://profiles.nlm.nih.gov/spotlight/px/feature/monster

With I. Haruna, I. B. Holland, G. Beaudreau, and D. Mlls. Digital facsimile from PubMedCentral at this link.


Subjects: BIOLOGY › MOLECULAR BIOLOGY › Nucleic Acids