An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15957 entries, 13939 authors and 1935 subjects. Updated: February 25, 2024


1 entries
  • 13952

Structure of the 30S ribosomal subunit.

Nature, 407, 327-339, 2000.

With Wimberly, Brian T.,  Brodersen, Ditlev E., Clemons, William M.,  Morgan-Warren, Robert J.,  Carter, Andrew P., Vonrhein, Clemens,  Hartsch, Thomas.

Ramakrishnan and colleagues determined the complete molecular structure of the 30S subunit of the ribosome and its complexes with several antibiotics. Ramakrishnan shared the 2009 Nobel Prize in Chemistry with Thomas A. Steitz and Ada Yonath, "for studies of the structure and function of the ribosome."
The Abstract:
"Genetic information encoded in messenger RNA is translated into protein by the ribosome, which is a large nucleoprotein complex comprising two subunits, denoted 30S and 50S in bacteria. Here we report the crystal structure of the 30S subunit from Thermus thermophilus, refined to 3Å resolution. The final atomic model rationalizes over four decades of biochemical data on the ribosome, and provides a wealth of information about RNA and protein structure, protein-RNA interactions and ribosome assembly. It is also a structural basis for analysis of the functions of the 30S subunit, such as decoding, and for understanding the action of antibiotics. The structure will facilitate the interpretation in molecular terms of lower resolution structural data on several functional states of the ribosome from electron microscopy and crystallography."

See also:
Ramakirshan, V., Wimberly, Brian T., Carter, et al, "Functional insights from the structure of the 20S ribosomal subunit and its interactions with antibiotics," Nature, 407 (2000) 340-348. And, Ramakirschan, Venki. Gene machine: The race to decipher the secrets of the ribsome (2018).

Subjects: BIOLOGY › Cell Biology, BIOLOGY › MOLECULAR BIOLOGY › Protein Synthesis