An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16019 entries, 14077 authors and 1941 subjects. Updated: July 25, 2024

CAMPBELL, William Cecil

3 entries
  • 12631

Avermectins, new family of potent anthelminthic agents, efficacy of the B1a component.

Antimicrobial agents and chemotherapy, 15, 372-378, 1979.

Campbell and colleagues reported unprecedented antiparasitic effects of the agent in vivo, and that the "B1a" component of the molecule was most effective as a single oral dose.
(Order of authorship in the original publication: Egerton, Oslin, Blair....Campbell.) Digital facsimile from PubMedCentral at this link.

In 2015 William C. Campbell shared half of the Nobel Prize in Physiology or Medicine with Satoshi Ōmura “for their discoveries concerning a novel therapy against infections caused by roundworm parasites.” The other half was awarded to Tu Youyou “for her discoveries concerning a novel therapy against Malaria.”

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: NOBEL PRIZES › Nobel Prize in Physiology or Medicine, PHARMACOLOGY › PHARMACEUTICALS › Antiparasitic Drugs
  • 12632

Ivermectin: A potent new antiparasitic agent.

Science, 221, 823-828, 1983.

Abstract

"Ivermectin is the 22,23-dihydro derivative of avermectin B1, a macrocyclic lactone produced by an actinomycete, Streptomyces avermitilis. It is active at extremely low dosage against a wide variety of nematode and arthropod parasites, apparently by virtue of its action on the mediation of neurotransmission by gamma-aminobutyric acid. It is now in commercial use in various countries for the treatment and control of parasites in cattle, horses, and sheep, and is expected to become available for use in swine and dogs. Since studies with the drug in man are in a preliminary stage, it is not yet known whether ivermectin will be useful in human medicine."

In 2015 the Nobel Prize in Physiology or Medicine 2015 was divided, one half jointly to William C. Campbell and Satoshi Ōmura "for their discoveries concerning a novel therapy against infections caused by roundworm parasites," and the other half to Tu Youyou "for her discoveries concerning a novel therapy against Malaria."

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: NOBEL PRIZES › Nobel Prize in Physiology or Medicine, PHARMACOLOGY › PHARMACEUTICALS › Antiparasitic Drugs, VETERINARY MEDICINE
  • 12658

Trichinella and trichinosis. Edited by William C. Campbell.

New York & London: Plenum Press, 1983.

The first chapter of this authoritative study is a very detailed historical introduction by William C. Campbell, with a comprehensive bibliography. Campbell also authored Chapter 10: Chemotherapy and Chapter 13: Epidemiology I: Modes of transmission. Chapter 14: Epidemiology II: Geographic distribution and prevalance by Charles W. Kim breaks down coverage to most countries and regions of the world.



Subjects: INFECTIOUS DISEASE › Food-Borne Diseases › Trichinosis, PARASITOLOGY › Trichinella