CAMPBELL, William Cecil
Avermectins, new family of potent anthelminthic agents, efficacy of the B1a component.Antimicrobial agents and chemotherapy, 15, 372-378, 1979.
Campbell and colleagues reported unprecedented antiparasitic effects of the agent in vivo, and that the "B1a" component of the molecule was most effective as a single oral dose.
Subjects: PHARMACOLOGY › PHARMACEUTICALS › Antiparasitic Drugs
Ivermectin: A potent new antiparasitic agent.Science, 221, 823-828, 1983.
"Ivermectin is the 22,23-dihydro derivative of avermectin B1, a macrocyclic lactone produced by an actinomycete, Streptomyces avermitilis. It is active at extremely low dosage against a wide variety of nematode and arthropod parasites, apparently by virtue of its action on the mediation of neurotransmission by gamma-aminobutyric acid. It is now in commercial use in various countries for the treatment and control of parasites in cattle, horses, and sheep, and is expected to become available for use in swine and dogs. Since studies with the drug in man are in a preliminary stage, it is not yet known whether ivermectin will be useful in human medicine."
Subjects: PHARMACOLOGY › PHARMACEUTICALS › Antiparasitic Drugs, VETERINARY MEDICINE
Trichinella and trichinosis. Edited by William C. Campbell.New York & London: Plenum Press, 1983.
The first chapter of this authoritative study is a very detailed historical introduction by William C. Campbell, with a comprehensive bibliography. Campbell also authored Chapter 10: Chemotherapy and Chapter 13: Epidemiology I: Modes of transmission. Chapter 14: Epidemiology II: Geographic distribution and prevalance by Charles W. Kim breaks down coverage to most countries and regions of the world.
Subjects: INFECTIOUS DISEASE › Food-Borne Diseases › Trichinosis, PARASITOLOGY › Trichinella