ALTER, Harvey James
(Order of authorship in the original publication: Blumberg, Alter, Visnich.) Discovery of Australia antigen, hepatitis B antigen, Aa, later called HBsAg. Blumberg received half of the Nobel Prize for Medicine in Biology in 1976 for the discovery of the antigen, for discovery of the hepatitis B virus, and for the discovery/ invention of the hepatitis B vaccine— the first cancer vaccine. See B. S. Blumberg, Hepatitis B: The Hunt for a Killer Virus (Princeton: Princeton University Press, 2002.)
Subjects: HEPATOLOGY › Diseases of the Liver, IMMUNOLOGY › Immunization, INFECTIOUS DISEASE › Hepatitis, VIROLOGY › VIRUSES (by Family) › Hepadnaviridae, VIROLOGY › VIRUSES (by Family) › Hepadnaviridae › Hepatitis B Virus
Lancet,1, 459-463, 1978.
The first paper recording the discovery of what was, eleven years later in 1989, named the hepatitis C virus (see No. 12653). Harvey Alter (Nobel Prize 2020) and colleagues inoculated the serum/plasma of 4 patients with non-A/non-B hepatitis into 5 chimps, and the chimps showed both biochemical and histological evidence of a typical hepatitis. The experiment was performed with a negative control. Order of authorship in the original paper: Alter, Purcell, Holland....
Subjects: VIROLOGY › VIRUSES (by Family) › Hepadnaviridae › Hepatitis C Virus