An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15959 entries, 13943 authors and 1935 subjects. Updated: March 1, 2024

AXEL, Richard

2 entries
  • 13929

Transformation of mammalian cells with genes from procaryotes and eucaryotes.

Cell, 16, 777-75, 1979.

Axel, along with microbiologist Saul J. Silverstein and geneticist Michael H. Wigler, discovered a technique of cotransformation via transfection. This process, which allows foreign DNA to be inserted into a host cell to produce certain proteins, is fundamental to recombinant DNA research at pharamceutical and biotech companies. Order of authorship in the original publication: Wigler, ...Silverstein, Axel.

Subjects: BIOLOGY › MOLECULAR BIOLOGY › Recombinant DNA, Biotechnology
  • 13930

A novel multigene family may encode odorant receptors: A molecular basis for odor recognition.

Cell, 65, 175-187, 1991.

"In their landmark paper published in 1991, Buck and Axel cloned olfactory receptors, showing that they belong to the family of G protein coupled receptors. By analyzing rat DNA, they estimated that there were approximately one thousand different genes for olfactory receptors in the mammalian genome. This research opened the door to the genetic and molecular analysis of the mechanisms of olfaction" (Wikipedia article on Richard Axel, accessed 7-22).
For this and later work showing that each olfactory receptor neuron expresses only one kind of olfactory receptor protein...Axel and Buck received the 2004 Nobel Prize in Physiology or Medicine.

Subjects: Olfaction / Smell, Anatomy & Physiology of