An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16018 entries, 14076 authors and 1941 subjects. Updated: July 23, 2024

Browse by Entry Number 2600–2699

183 entries
  • 2600

The physiology of the immediate reaction of anaphylaxis in the guinea-pig.

J. exp. Med. 12, 151-75, 1910.

First adequate account of the physiological reactions leading to fatal anaphylactic shock.

  • 2600.1

Bronchial asthma as a phenomenon of anaphylaxis.

J. Amer. med. Assoc. 55, 1021-24, 1910.

The work of Auer and Lewis (see No. 2600) led Meitzer to the conclusion that bronchial asthma was due to anaphylaxis, although he did not appreciate that not all cases of asthma were so caused.

Subjects: ALLERGY › Anaphylaxis, ALLERGY › Asthma
  • 2600.2

Physiological studies in anaphylaxis. I. The reaction of smooth muscle of the guinea-pig sensitized with horse serum.

J. Pharmacol. 1, 549-67, 1910.

Schultz-Dale test for anaphylaxis. See also No. 2600.5

Subjects: ALLERGY › Anaphylaxis
  • 2600.3

Prophylactic inoculation against hay fever.

Lancet, 1, 1572-73, 1911.

Noon and Freeman introduced the treatment of hay fever by means of injections of pollen extract.

Subjects: ALLERGY
  • 2600.4

Further observations on the treatment of hay fever by hypodermic inoculations of pollen vaccine.

Lancet, 2, 814-17, 1911.

See No. 2600.3.

Subjects: ALLERGY, IMMUNOLOGY › Vaccines
  • 2600.5

The anaphylactic reaction of plain muscle in the guinea-pig.

J. Pharmacol. 4, 167-223, 1913.

See No. 2600.2. Dale concluded that histamine induced hypersensitivity reactions.

Subjects: ALLERGY › Anaphylaxis
  • 2600.6

Human sensitization.

J. Immunol, 1, 201-305, 1916.

The concept of atopy had its origin in the report by Cooke and Vander Veer in 1916.

  • 2601

Anaphylaxie et antianaphylaxie.

Paris: Masson & Cie, 1917.

English translation, 1919.

Subjects: ALLERGY › Anaphylaxis
  • 2601.1

Studien über die Ueberempfindlichkeit.

Zbl. Bakt., I Abt. Orig. 86, 160-69, 1921.

Prausnitz–Küstner reaction. These workers demonstrated antibodies in the blood of persons suffering from atopic allergic diseases. They produced local passive sensitization by intracutaneous injection of serum from a hypersensitive subject. Prausnitz spent his later years in England, where he adopted the surname Prausnitz Giles. Translated by Prausnitz in Clinical aspects of immunology (P.G.H.Gell & R.R.A. Coombs, eds.) Oxford, 1962, pp. 808-16.

  • 2602

Vascular reactions of the skin to injury. II. The liberation of a histamine-like substance in injured skin; the underlying cause of factitious urticaria and of wheals produced by burning; and observations upon the nervous control of certain skin reactions.

Heart, 11, 209-65, 1924.

Lewis postulated that a histamine-like substance (“H-substance”) was responsible for the anaphylaxis symptom-complex. See also The blood-vessels of the human skin and their responses, 1927 (No. 797).

  • 2603

Allergic diseases; diagnosis and treatment of bronchial asthma, hay fever, and other allergic diseases.

Philadelphia: J. B. Lippincott, 1925.

In his important studies of asthma, Storm van Leeuwen demonstrated that in the great majority of patients allergens are the cause of the condition and also that patients are sensitive to mold spores. He experimented with an allergen-proof chamber and showed the benefit of high altitude to asthmatics.

Subjects: ALLERGY › Asthma
  • 2603.1

Arsphenamine hypersensitiveness in guinea pigs. II. Experiments demonstrating the role of the skin, both as originator and as site of the hypersensitiveness.

Arch. Dermatol. Syph., 22, 839-849, 1930.

Sulzberger showed that allergens gaining access to the epidermis are processed there in some manner (Langerhans cells?) that determines their allergenicity. See No. 2576.02

  • 2604

Treatment of hay fever by intranasal zinc ionization.

Brit. med. J.1, 1115-16, 1931.

Introduction of the method.

Subjects: ALLERGY
  • 2605

Studies in anaphylaxis.

Amer. J. Physiol.102, 512-26, 1932.

Detection of the release of histamines into the circulation during anaphylactic reaction. Thereafter histamine was identified as Lewis’s “H-substance.”

Subjects: ALLERGY › Anaphylaxis
  • 2605.1

Experiments in silk hypersensitivity and the inhalation of allergen in atopic dermatitis (neurodermatitis disseminatus).

J. Allergy, 5, 554-569, 1934.

Proof that inhaled allergens can reach the skin in a quantity and quality capable of eliciting urticarial reactions. With W.T. Vaughn. Coca and Sulzberger coined the term, “atopic dermatitis.”

  • 2605.2

Penetration of allergens into the human skin.

N. Y. State J. Med. 44, 2452-2459, 1944.

Proof that allergens that produce urticarial reactions can penetrate the skin from external contact and thus produce the reaction that the authors named “contact urticaria.” With F. Herrmann and R. Baer.

  • 2606

De tumoribus praeter naturam. In his Opera omnia, ed. cur. C.G. Kühn. 7, 705-32.

Leipzig: C. Cnobloch, 1824.

Galen’s classification of tumors persisted for more than 1,000 years. He considered neoplasms to be due to an excess of black bile, which solidified in certain sites. He advocated purges to dissolve the black bile, and if these were unsuccessful, the knife. He was not familiar with internal tumors. Critical edition and English translation by J. Reedy, Diss, (not published,) University of Michigan, 1968.

  • 2607

Mémoire avec un précis de plusieurs observations sur le cancer.

Mém. Acad. roy. Chir. (Paris), 3, 1-54, 1757.

Le Dran discarded the humoral conception of cancer for the first time. He regarded cancer as a local disease in its early stage and knew that it spread via the lymphatics to regional nodes, and from there into the general circulation. He described with great clarity the path of metastasis in breast carcinoma, including involvement of the lungs.

  • 2607.1

Cautions against the immoderate use of snuff. Founded on the known qualities of the tobacco Plant; and the effects it must produce when this way taken Into the body: And by instances of persons who have perished miserably of diseases, occasioned, or rendered incurable by its use,

London: R. Baldwin & J. Jackson, 1761.

First clinical report (pp. 30-31) of an association between tobacco and cancer, in this case “polypusses” of the nose caused by taking snuff. Hill was a distinguished botanist and apothecary, although regarded by some as a quack. See D.E. Redmond, Jr., Tobacco and cancer: the first clinical report. New Eng. J. Med., (1970), 282, 18-23.

Digital facsimile of the second edition, also published in 1761, from the Internet Archive at this link.

Subjects: ONCOLOGY & CANCER, PHARMACOLOGY › PHARMACEUTICALS › Botanic Sources of Single Component Drugs › Tobacco, TOXICOLOGY › Drug Addiction › Tobacco
  • 2608

Dissertatio academica de cancro.

Paris: apud De Hansy juniorem, 1774.

Peyrilhe was the first to attempt an experimental study to determine the nature of cancer. He injected fluid from human mammary cancer into a dog; however, the dog howled and aggravated his housekeeper, who drowned it. Peyrilhe recognized for the first time the essential unity of the many different forms of cancer. French edition, 1776. English translation, London, 1777. Digital facsimile of the 1774 edition from Google Books at this link.

  • 2122
  • 2609
  • 4165

Chirurgical observations relative to the cataract, the polypus of the nose, the cancer of the scrotum, etc.

London: L. Hawes, 1775.

Includes the first description of occupational cancer. By describing chimney sweeps” cancer of the scrotum, Pott was the first to trace the origin of a type of cancer to a specific external cause. The above work also includes his description of senile gangrene, sometimes referred to as “Pott’s gangrene”.

  • 2609.1

De morbis vasorum absorbentium corporis humani.

Frankfurt: Varrentrapp & Wenner, 1795.

Soemmerring noted an association between pipe smoking and cancer of the lip (p. 109).

Subjects: ONCOLOGY & CANCER, PHARMACOLOGY › PHARMACEUTICALS › Botanic Sources of Single Component Drugs › Tobacco, TOXICOLOGY › Drug Addiction
  • 2610

Recherches sur le traitement du cancer par la compression méthodique. 2 vols.

Paris: Gabon, 1829.

Récamier was the first to recognize the process of metastasis. He also described for the first time invasion of veins by cancer.

  • 2611

A short tract on the formation of tumours, and the peculiarities that are met with in the structure of those that have become cancerous; with their mode of treatment.

London: Longman, 1830.

Contains the first illustrations of microscopic sections of cancer; however, Home drew no worthwhile conclusion from his microscopic studies. Digital facsimile from the Internet Archive at this link.

Subjects: ANATOMY › Anatomical Illustration, ANATOMY › Microscopic Anatomy (Histology), ONCOLOGY & CANCER
  • 2611.1

Surgical observations on tumours, with cases and operations.

Boston, MA: Crocker & Brewster, 1837.

The first North American book on tumors, with 16 hand-colored plates by David Claypoole Johnston (1799-1865).

Subjects: Illustration, Biomedical, ONCOLOGY & CANCER
  • 2612

Ueber den feinern Bau und die Formen der krankhaften Geschwülste. Lief. 1.

Berlin: G. Reimer, 1838.

This classic work showed that Müller realized the necessity of the cell theory for the comprehension of the nature of cancer. He recognized cells, their nuclei and nucleoli, and could distinguish various types of tumors microscopically. Only Lieferung 1 of the book was published; C. West translated it into English in 1840. Improved translation with important commentary in L.J. Rather, P. Rather, & J.B. Frerichs, Johannes Müller and the nineteenth-century origins of tumor cell theory, Canton, Mass, Science History Publications, [1986].

  • 2612.1

The nature and treatment of cancer.

London: Taylor & Walton, 1846.

The earliest account of the recognition of fragments of malignant tissue. Digital facsimile from Google Books at this link

  • 2613

Zur Entwickelungsgeschichte des Krebses.

Virchows Arch. path. Anat.1, 94-201, 1847.

While still a young man Virchow founded the above journal. He wrote a fine paper on cancer and suggested that the exciting cause is local irritation.

  • 2614

Transplantation of malignant tumors.

Proc. Acad. nat. Sci. Philad. 5, 212, 1851.

First experimental transplantation of tumors.

  • 2615

Om epithelioma, en særegen Svulst, som man hidtil i Almindelighed har anseet for Kræft.

Copenhagen: Universitetsboghandler G. U. Reisels Forlag, 1852.

Hannover coined the word “epithelioma.” He did not recognize its malignant character but maintained that metastases were produced by cancer cells arriving by way of the blood stream. Translated into German as Das Epithelioma, Leipzig: L. Voss, 1852.

  • 2616

Clinical memoirs on abdominal tumours and intumescence.

London: New Sydenham Society, 1860.

  • 2617

Die krankhaften Geschwülste. Vol. 1-3, Heft 1.

Berlin: A. Hirschwald, 18631867.

Although tumours were perhaps his greatest interest, Virchow never completed this work which was intended to have 30 lectures. Instead he stopped with the 25th lecture, on carcinoma, probably because of the vigorous attack which Remak and others were making on his conception of the histogenesis of epithelioma. Virchow’s 25th lecture records one of his mistakes – his theory of the connective-tissue origin of carcinoma. So great was Virchow’s influence that this error was not generally recognized until the work of Waldeyer (see No. 2620).

  • 2618

Der Epithelialkrebs namentlich der Haut. 1 vol. and atlas.

Leipzig: Wilhelm Engelmann, 1865.

Thiersch, Professor of Surgery at Erlangen, and inventor of the method of skin grafting which bears his name, also made an important contribution to the knowledge of the histogenesis of cancer. He disproved Virchow’s theory of the connective-tissue origin of cancer, and advanced evidence of its epithelial cell origin. Digital facsimile from the Internet Archive at this link.

  • 2619

On the influence of inadequate operations on the theory of cancer.

Med.-chir. Trans. 50, 245-80, 1867.

Modern surgical treatment of cancer is based upon principles laid down by Moore. For cancer of the breast he showed that recurrence was not due to the development of an entirely new tumor because of constitutional susceptibility, as was then generally theorized, but to incomplete removal of the original tumor. He insisted that the entire breast be carefully removed in every case of breast cancer.

  • 2620

Die Entwicklung der Carcinome.

Virchows Arch. path, Anat. 41, 470-523, 55, 67-159, 1867, 1872.

Waldeyer confirmed the work of Thiersch (No. 2618) on the epithelial origin of cancer, disproving Virchow’s theory (No. 2617). So great was the authority of the latter that it was not until the appearance of the second of the above papers that Virchow’s error was finally recognized.

  • 2620.1

O privivanii rakovikh novoobrazovanii. [On the inoculation of cancerous neoplasms.]

Med. Vestn.,16, 289-90, 1876.

Novinsky successfully transplanted two tumors in dogs. German translation in Zbl. med. Wiss., 1876, 14, 790-91. A fuller report appeared in his thesis K voprosu o privivanii zlokachestvennich novoobrazovanii (eksperimentalnoi issledovanii). [On the question of inoculation of malignant neoplasms (experimental investigations)]. St. Petersburg, 1877.

  • 2620.2

Demonstration der durch Impfung von Hund auf Hund erzeugten Carcinomknötchen.

Verh. dtsch. Ges. Chir.17, 52-53, 1888.

A tumor transplant from dog to dog was reported by Wehr.

  • 2621

Erfolgreiche experimentelle Uebertragung von Carcinom.

Fortschr. Med. 7, 321-39, 1889.

Hanau successfully transplanted cancer in mammals.

  • 2622

An address on a characteristic organism of cancer.

Brit. med. J. 2, 1356-60, 1890.

“Russell’s bodies.”

  • 2622.1

Inoculation en série d’une tumeur épithéliale de la souris blanche.

C. R. Soc. Biol. 43, 289-90, 1891.

In 1889 Morau transferred epitheliomata in mice and by 1893 had carried his experiments through 17 generations, the first systematic survey of tumor-host relationships from a purely biological viewpoint.

Subjects: DERMATOLOGY › Dermatopathology, ONCOLOGY & CANCER
  • 2623
  • 3773

Ueber Lympho-Sarkomatosis.

Wien. klin. Wschr. 6, 211-13, 234-39, 1893.

Kundrat separated lymphosarcoma (“Kundrat’s disease”) from other malignant tumors involving the lymphatic system.

Subjects: ONCOLOGY & CANCER, Spleen: Lymphatics
  • 2624

Fall af epiteliom behandladt med Roentgenstraler.

Förh. Svenska Läkare-Sallskapets Sammankomster, Stockholm, p. 208, 1899.

In June 1899 Sjögren was the first successfully to use Roentgen rays in the treatment of cancer.

Subjects: DERMATOLOGY, ONCOLOGY & CANCER › Radiation (Radiotherapy)
  • 2624.1

On transplantation of tumours.

J. med. Res. 6, 28-38, 1901.

Loeb successfully transplanted cystic sarcoma of the thyroid in rats. He established the fact that growth of the transplant occurred through proliferation of its peripheral cells.

  • 2625

Die Lehre von den Geschwülsten. 2 vols.

Wiesbaden: J. F. Bergmann, 1902.

“With this book the microscopical epoch in the evolution of the knowledge of cancer may be said to have been brought to a close” (Haagensen).

Subjects: Microscopy, ONCOLOGY & CANCER
  • 2625.1

Cancroid des rechten Handrückens.

Dtsch. med. Wschr. 28, Vereins-Beilage, 335, 1902.

Frieben reported the carcinogenic effect of x-rays in man.

  • 2626

Die mikroskopische Diagnose der bösartigen Geschwülste. 2te. Aufl.

Berlin: A. Hirschwald, 1902.

Hansemann originated the theory of anaplasia.

  • 2627

Zur Frage der Beziehungen zwischen Becquerelstrahlen und Hautaffectionen.

Derm. Z.10, 457-62, 1903.

Records the first successful employment of radium in the treatment of cancer.

Subjects: DERMATOLOGY, ONCOLOGY & CANCER › Radiation (Radiotherapy)
  • 2627.1

Ueber den Einfluss der Röntgenstrahlen auf epitheliale Gewebe, insbesondere auf das Carcinom.

Arch. klin. Chir. 71, 955-1000, 1903.

Perthes was among the first to study the inhibitory effect of x rays on carcinoma; he was a pioneer in radiotherapy.

Subjects: DERMATOLOGY, ONCOLOGY & CANCER › Carcinoma, ONCOLOGY & CANCER › Radiation (Radiotherapy)
  • 2628

Experimentelle Untersuchungen über Krebs bei Mäusen.

Zbl. Bakt. Abt. I, Orig., 34, 28-34, 122-43, 1903.

Jensen carried rat sarcoma through as many as 40 generations of rodents without change in microscopic structure. His classic study discredited the theory of the infectivity of cancer, and established its inoculability. See also Z. Krebsforsch., 1909, 7, 45-54.

  • 2629

Die Verbreitungswege der Karzinome und die Beziehung generalisierter Sarkome zu den leukämischen Neubildungen.

Jena: Gustav Fischer, 1903.

Schmidt supported the theory of the hematogenous origin of carcinoma metastases.

Subjects: ONCOLOGY & CANCER › Carcinoma, ONCOLOGY & CANCER › Leukemia, ONCOLOGY & CANCER › Sarcoma
  • 2630

Om Röntgenbehandling af sarkom.

. Hygiea, 2 F. 4, 1142-49, 1904.

Subjects: ONCOLOGY & CANCER › Radiation (Radiotherapy)
  • 2631

Om Röntgenbehandling af maligna svulster.

Nord. T. Terapi, 3, 8-23, 19041905.

SeeNo. 2624.

Subjects: ONCOLOGY & CANCER › Radiation (Radiotherapy)
  • 2632

Die Entstehung des Carcinoms.

Bonn: F. Cohen, 1905.

Ribbert was the modern protagonist of the theory of the embryonal origin of cancer.

  • 2633

A study of heredity in relation to the development of tumours in mice.

J. med. Res.17, 199-211, 19071908.

First experimental study of the heredity of mouse cancer.

  • 2634

Chronisch entzündliche Bauchdeckengeschwülste nach Bruchoperationen.

Zbl. Chir. 35, Beilage, 113-15, 1908.

“Schloffer’s tumor” – a rare inflammatory pseudotumor of the abdomen. It usually appears several years after abdominal surgery, including herniotomy, or trauma.

Subjects: SURGERY: General › Hernia
  • 2635

The Croonian Lectures on radioactivity and carcinoma.

Brit. med. J.1, 1465-70, 1536-44, 1909.

Subjects: ONCOLOGY & CANCER › Carcinoma, ONCOLOGY & CANCER › Radiation (Radiotherapy)
  • 2636

Cultures de sarcome en dehors de l’organisme.

C. R. Soc. Biol. (Paris) 69, 332-34, 1910.

Using the Rous chicken sarcoma, Carrel and Burrows were the first to grow tumor tissue in vitro.

Subjects: ONCOLOGY & CANCER › Sarcoma › Soft Tissue Sarcoma, VIROLOGY › VIRUSES (by Family) › Retroviridae › Rous Sarcoma Virus (RSV)
  • 2637

A transmissible avian neoplasm (sarcoma of the common fowl).

J. exp. Med., 12, 696-705; 13, 397-411, 1910, 1911.

Original description of the chicken sarcoma (Rous sarcoma). Rous demonstrated that sarcomatous tumors in hens could be transmitted to normal hens by the injection of cell-free filtrates (virus) of the original tumor. The Rous Sarcoma Virus was the first oncovirus discovered.

Fifty-five years later, in 1966 Rous shared the Nobel Prize in Physiology or Medicine with Charles Huggins "for his discovery of tumor-inducing viruses and his work on cancer."

Subjects: NOBEL PRIZES › Nobel Prize in Physiology or Medicine, ONCOLOGY & CANCER › Sarcoma › Soft Tissue Sarcoma, VIROLOGY › VIRUSES (by Family) › Retroviridae › Rous Sarcoma Virus (RSV)
  • 2637.1

Le cancer expérimental.

J. méd. franç. 5, 299-305, 1911.

Experimental production of malignant tumors by means of x rays.

  • 2638

Zur Diagnose des Karzinoms.

Wien. klin. Wschr. 24, 1759-64, 1911.

A serum reaction, employed by Freund and Kaminer in 1910 for the diagnosis of cancer.

Subjects: ONCOLOGY & CANCER, WOMEN, Publications by, WOMEN, Publications by › Years 1900 - 1999
  • 2639

Epithelial proliferation induced by the injection of gasworks tar.

Lancet, 2, 1579, 1912.

Experimental production of cancer by the injection of tar as a byproduct of the manufacture of coal gas.

  • 2640

Untersuchungen über eine Nematode (Spiroptera sp. n.) und deren Fähigkeit papillomatöse und carcinomatose Geschwulstbildungen im Magen der Ratte hervorzurufen.

z. Krebsforsch.13, 217-80; 14, 295-326, 1913, 1914.

Fibiger demonstrated that the roundworm, which he called Spiroptera carcinoma (but is correctly named Gongylonema neoplasticum), could cause stomach cancer (squamous cell carcinoma) in rats and mice. His experimental results were later proven to be a case of "mistaken conclusion."

In 1926 Fibiger was awarded the 1926 Nobel Prize in Physiology or Medicine "for his discovery of the Spiroptera carcinoma."

Subjects: NOBEL PRIZES › Nobel Prize in Physiology or Medicine, ONCOLOGY & CANCER, ONCOLOGY & CANCER › Carcinoma
  • 2641

The mortality from cancer throughout the world.

Newark, NJ: Prudential Press, 1915.

Subjects: DEMOGRAPHY / Population: Medical Statistics, ONCOLOGY & CANCER
  • 2642

Further investigations on the origin of tumours in mice. III. On the part played by internal secretion in the spontaneous development of tumours.

J. Cancer Res. 1, 1-19, 1916.

Demonstration of the influence of an internal secretion on the development of spontaneous cancer. Castration of female mice of a strain in which mammary cancer was frequent reduced its incidence and delayed its growth.

Subjects: ENDOCRINOLOGY, ONCOLOGY & CANCER, WOMEN, Publications by › Years 1900 - 1999
  • 2643

Ueber die künstliche Erzeugung von Karzinom.

Verh. jap. path. Ges. 6, 169-78; 7, 191-96, 1916, 1917.

First experimental production of tar cancer in rabbits by painting with tar products. This was the first proof of chemical carcinogenesis.

  • 2644

Neoplastic diseases.

Philadelphia: W. B. Saunders, 1919.

Fourth edition, 1940.

  • 2645

Squamous-cell epithelioma of the lip. A study of five hundred and thirty-seven cases.

J. Amer. med. Assoc., 74, 656-64, 1920.

Broders’s classification of tumors, an index of malignancy.

Subjects: DERMATOLOGY › Dermatopathology, DERMATOLOGY › Skin Cancer › Squamous Cell Carcinoma
  • 2645.1

A preliminary report on the experimental production of sarcoma of the liver of rats.

Proc. Soc. exp. Biol. (N.Y.) 18, 29-30, 1920.

Proof that cancer can be caused by a parasite, Cysticercus fasciolaris, the larval stage of Taenia crassicolis. With M. R. Curtis and G. L. Rohdenberg. See also Proc. N.Y. path. Soc., 1920, 20, 149-75.

Subjects: ONCOLOGY & CANCER, ONCOLOGY & CANCER › Sarcoma › Soft Tissue Sarcoma, PARASITOLOGY
  • 2646

The formation of a cancer-producing substance from isoprene (2-methyl-butadiene).

J. Path. Bact., 27, 233-38, 1924.

Kennaway produced carcinogenic tars by submitting acetylene or isoprene to high temperatures in an atmosphere of hydrogen, thus proving that some carcinogens are pure hydrocarbons.

  • 2647

The aetiology of malignant new growths.

Lancet, 2, 109-17, 1925.

Gye advanced the theory that an ultramicroscopic virus combined with an intrinsic chemical factor were concerned in the production of the Rous sarcoma.

Subjects: ONCOLOGY & CANCER, VIROLOGY › VIRUSES (by Family) › Retroviridae › Rous Sarcoma Virus (RSV)
  • 2648

The microscopical examination of filterable viruses associated with malignant new growths.

Lancet, 2, 117-23, 1925.

Barnard supported, with photomicrographs, Gye’s theory concerning the origin of cancer.

  • 2649

The melanomata, their morphology and histogenesis. A study of cell origins and transformations, with a critical discussion on aspects of tumour growth, and a clinical review.

Edinb. med. J., 32, 501-732, 1925.
The first exhaustive monograph on  the pathology of melanoma.  Also issued as a separate monograph (Edinburgh: Oliver & Boyd, 1925).

Subjects: DERMATOLOGY › Dermatopathology, DERMATOLOGY › Skin Cancer › Melanoma, ONCOLOGY & CANCER › Melanoma
  • 2650

Haemagglutinegehalte van het bloedserum bij carcinoompatiënten.

Ned. T. Geneesk.70, i, 2856-58, 1926.

Bendien test for the diagnosis of cancer. He published books in German and English on this subject in 1931. Modification by E. C. Lowe, Brit. med. J., 1932, 2, 1060.

Subjects: Laboratory Medicine › Blood Tests, ONCOLOGY & CANCER
  • 2651

Ueber den Stoffwechsel der Tumoren.

Berlin: Julius Springer, 1926.

In his important studies of the metabolism of tumors, Warburg was first to observe that malignant tissue utilizes glucose by glycolysis, whether or not oxygen is available (aerobic glycolysis). English translation, 1930.

  • 2652

Cancer and heredity.

Ann. intern. Med. 1, 951-76, 1928.

By selective breeding over a period of 15 years, Slye produced generations of mice absolutely resistant to, or particularly susceptible to, cancer. She demonstrated that resistance is a Mendelian dominant and susceptibility a recessive, either of which can be bred into or out of susceptible or resistant generations, according to the laws of genetics. Her earlier papers are in J. med. Res., 1914, 25, 281; 1915, 27, 159; J Cancer Res., 1916, 1, 479, 503; 1921, 6, 139; 1922, 7, 107.

Subjects: GENETICS / HEREDITY › HEREDITARY / CONGENITAL DISEASES OR DISORDERS › Hereditary Cancers, ONCOLOGY & CANCER, WOMEN, Publications by › Years 1900 - 1999
  • 2652.1

Über ein neues Prinzip zur Herstellung höher Spannungen.

Arch. Elektrotech. 21, 387-406, 1928.

RF-powered linear accelerator.

Subjects: ONCOLOGY & CANCER › Radiation (Radiotherapy)
  • 2653

Allergie des Lebensalters, die bösartigen Geschwülste.

Leipzig: G. Thieme, 1930.

Important study of the age and sex incidence of cancer.

  • 2654

The production of cancer by pure hydrocarbons.

Proc. roy. Soc. B, 111, 455-96, 1932.

Discovery of the carcinogenic properties of dibenzanthracene compounds. With I. Hieger, E. L. Kennaway, and W. V. Mayneord.

  • 2655

Superior pulmonary sulcus tumor. Tumor characterized by pain. Horner’s syndrome, destruction of bone and atrophy of hand muscles.

J. Amer. med. Assoc. 99, 1391-96, 1932.

“Pancoast’s tumor.”

  • 2656

A transmissible tumor-like condition in rabbits.

J. exp. Med. 56, 793-802, 1932.

Shope papilloma virus (SPV), a benign infectious tumor due to a virus. This was the first mammalian tumor virus discovered. Full text from PubMedCentral at this link.

See also Shope, "Infectious Papillomatosis of Rabbits with a note on the histopathology"The Journal of Experimental Medicine, 58 (1933) 607–624, the full text of which is also available from PubMedCentral.

  • 2657
  • 5787

Apparition de cancers de la mamelle chez la souris mâle, soumise à des injections de folliculine.

C. R. Acad. Sci. (Paris), 195, 630-632, 1932.

Demonstration of the carcinogenic effect of ovarian hormone.

  • 2658

Some possible effects of nursing on the mammary gland tumor incidence in mice.

Science, 84, 162, 1936.

Bittner’s “milk factor,” the murine mammary tumor involved in the transmission of cancer in mice. See also Amer. J. clin. Path., 1937, 7, 430-35.

  • 2659

The carcinogenic action of oestrone: induction of mammary carcinoma in female mice of a strain refractory to the spontaneous development of mammary tumours.

J. Path. Bact. 45, 709-14, 1937.

With L. H. Stickland and K. I. Connal.

Subjects: ONCOLOGY & CANCER › Carcinoma, WOMEN, Publications by › Years 1900 - 1999
  • 2010.2
  • 2659.1

Acceleration of electrons by magnetic induction.

Phys. Rev., 58, 841, 1940.


Continued as Kerst, "The acceleration of elecrons by magnetic induction," Phys. Rev., 60 (1941) 47-52. Digital facsimile of the 1941 paper at this link.

Subjects: Nuclear Medicine, ONCOLOGY & CANCER › Radiation (Radiotherapy)
  • 2659.2

“Folic acid” a tumor growth inhibitor.

Proc. Soc. exp. Biol. (N.Y.), 55, 204-05, 1944.

Inhibition of tumor growth by a folic acid concentrate. With R. Lewisohn, D. Laszlo. These workers later (Proc. Soc. exp. Biol. N. Y., 1944, 56, 144-45) obtained similar results with xanthopterin.

Subjects: ONCOLOGY & CANCER, WOMEN, Publications by › Years 1900 - 1999
  • 2659.3

Influence of synthetic oestrogens upon advanced malignant disease.

Brit. med. J. 2, 393-98, 1944.

Administration of synthetic estrogens in advanced mammary cancer caused regression of tumors. With J. M. Watkinson, E. Paterson, and P. C. Koller.

  • 2659.4

The synchrotron: a proposed high energy particle accelerator.

Phys. Rev. 68, 143-144, 1945.

In 1951 McMillan shared the Nobel Prize in Chemistry with Glenn Theodore Seaborg "for their discoveries in the chemistry of the transuranium elements."

Subjects: NOBEL PRIZES › Nobel Prize in Chemistry, ONCOLOGY & CANCER › Radiation (Radiotherapy)
  • 2659.5

The design of a proton linear accelerator.

Phys. Rev. 70, 799-800, 1946.

Linear ion accelerator.

In 1968 Alvarez received the Nobel Prize in Physics "for his decisive contributions to elementary particle physics, in particular the discovery of a large number of resonance states, made possible through his development of the technique of using hydrogen bubble chamber and data analysis."

Subjects: NOBEL PRIZES › Nobel Prize in Physics, Nuclear Medicine, ONCOLOGY & CANCER › Radiation (Radiotherapy)
  • 10133
  • 2659.6

Nitrogen mustard therapy. Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders.

J. Amer. Med. Assoc., 132 (3), 126-132, 1946.

Widely considered the first uses of chemotherapy for the treatment of malignant diseases.

Subjects: ONCOLOGY & CANCER › Chemotherapy for Cancer, ONCOLOGY & CANCER › Leukemia, ONCOLOGY & CANCER › Lymphoma
  • 2660

Effect of intraperitoneal injection of malignant urine extracts in normal and hypophysectomized rats.

Science, 105, 475-76, 1947.

Test for diagnosis of cancer. With B. Halperin and S. H. Libert.

  • 2660.1

Temporary remissions in acute leukemia in children produced by folic acid antagonist 4-amethopteroylglutamic acid (aminopterin).

New Engl. J. Med. 238, 787-93, 1948.

With L. K. Diamond, R. D. Mercer, R. F. Sylvester, and V. A. Wolff.

  • 2660.10

The induction of neoplasms with a substance released from mouse tumors by tissue culture.

Virology, 3, 380-400, 1957.

Isolation of polymavirus (papovavirus). With B. E. Eddy, A. M. Gochenour, N. G. Borgese, and G E. Grubbs.

Subjects: ONCOLOGY & CANCER, VIROLOGY, WOMEN in Medicine & the Life Sciences, Publications About
  • 2660.11

Neuartige Krebs-Chemotherapeutica aus der Gruppe der zyklischen N-Lost-Phosphamidester.

Naturwissenschaften, 45, 64-66, 1958.

Cyclophosphamide. With F. Bourseaux and N. Brock.

  • 2660.12

A sarcoma involving the jaws in African children.

Brit J. Surg., 46, 218-23, 19581959.

Burkitt’s lymphoma (African lymphoma), first described in detail by Sir Albert Cook, a medical missionary, but not published by him.

  • 2660.13

Virus-cell interaction with a tumour-producing virus.

Proc. Nat. Acad. Sci. (Wash.), 46, 365-70, 1960.

Polyomavirus (papovavirus) shown to be capable of transforming cells in culture.  Full text from PubMedCentral at this link.

Subjects: ONCOLOGY & CANCER, VIROLOGY, WOMEN, Publications by › Years 1900 - 1999
  • 2660.14

Evidence that the L-asparaginase of guinea pig serum is responsible for its antilymphoma effects.

J. exp. Med. 118, 99-148, 1963.

  • 2660.15

Pre-therapeutic experiments with the fast neutron beam from the Medical Research Council cyclotron. A symposium.

Brit. J. Radiol., 36, 77-121, 1963.

Subjects: ONCOLOGY & CANCER › Radiation (Radiotherapy)
  • 2660.16
  • 3788.2

The Vinca alkaloids: a new class of oncolytic agents.

Cancer Res., 23, 1390-1427, 1963.

Clinical use of vinblastine (for Hodgkin’s disease and other lymphomas) and vincristine (for acute leukemias of childhood). With J. G. Armstrong, M. Gorman, and J. P. Burnett. Preliminary communication in J. Lab. clin. Med., 1959, 54, 830.

Subjects: ONCOLOGY & CANCER, PHARMACOLOGY › PHARMACEUTICALS › Anti-Cancer Drugs, Spleen: Lymphatics
  • 2660.17

Cultivation in vitro of human lymphoblasts from Burkitt’s malignant lymphoma.

Lancet, 1, 252-3, 1964.

Order of authorship in the original publication: Epstein, Barr. Discovery of the Epstein-Barr virus, a human herpes virus causing infectious mononucleosis, and implicated in Burkitt’s lymphoma and other forms of cancer. The Epstein-Barr virus was the first human cancer-causing virus discovered. This was the authors' first publication of the discovery. A few issues of Nature later they followed this paper with a second paper, No. 2660.18.

Subjects: INFECTIOUS DISEASE › Infectious Mononucleosis, ONCOLOGY & CANCER › Lymphoma, VIROLOGY, VIROLOGY › VIRUSES (by Family) › Herpesviridae, VIROLOGY › VIRUSES (by Family) › Herpesviridae › Epstein-Barr Virus, WOMEN, Publications by › Years 1900 - 1999
  • 2660.18

Virus particles in cultured lymphoblasts from Burkitt’s lymphoma.

Lancet, 1, 702-3, 1964.

Order of authorship in the original publication: Epstein, Achong, Barr. Presence of herpes-like virus particles in Burkitt’s tumor cells reported. The Epstein-Barr virus was the first human cancer-causing virus to be discovered.

Subjects: ONCOLOGY & CANCER › Lymphoma, VIROLOGY, VIROLOGY › VIRUSES (by Family) › Herpesviridae › Epstein-Barr Virus, WOMEN, Publications by › Years 1900 - 1999
  • 2660.19

Cytology of Burkitt’s tumour (African lymphoma).

Lancet, 1, 238-40, 1964.

  • 2660.2

A sensitive directional gamma-ray detector.

Nucleonics, 6, 78-81, 1950.

Directional scintillation detector probe. Cassen assembled the first automated scanning system, comprised of a motor driven scintillation detector coupled to a relay printer. The scanner was initially used to image thyroid glands after the administration of radioiodine.  Later, with the development of organ-specific radiopharmaceuticals, the scanner was widely used during the late 50s until the early 70s to image body organs. With L. Curtis and C. W. Reed.

Subjects: IMAGING, Nuclear Medicine, ONCOLOGY & CANCER
  • 2660.21

Statistical studies in the aetiology of malignant neoplasms. 5 vols.

Copenhagen, Ejnar Munksgaard, 19651977.

Acta path. microbiol. scand., Suppl. 174 (Pts. 1-2), 209, 247, 261.

  • 2660.22

Viral RNA-dependent DNA polymerase: RNA-dependent DNA polymerase in virions of RNA tumour viruses.

Nature (Lond.), 226, 1209-11, 1970.

In 1970 Baltimore and Temin discovered that certain viruses that have their genes in the form of RNA can copy the RNA "backward" into DNA in infected cells. The enyzme, reverse transcriptase, enables the manufacture of specific proteins for use as medicines.

Baltimore, who was the only author of this paper, shared the 1975 Nobel Prize in Physiology or Medicine with R. Dulbecco and H. M. Temin "for their discoveries concerning the interaction between tumour viruses and the genetic material of the cell."

Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Synthesis, NOBEL PRIZES › Nobel Prize in Physiology or Medicine, ONCOLOGY & CANCER, VIROLOGY › Molecular Virology
  • 2660.23

RNA-dependent DNA polymerase in virions of Rous sarcoma virus.

Nature (Lond.), 226, 1211-13, 1970.

Discovery of reverse transcriptase. "In 1969, Temin and a postdoctoral fellow, Satoshi Mizutani, began searching for the enzyme that was responsible for the phenomenon of viral RNA being transferred into proviral DNA. Later that year, Temin showed that certain tumor viruses carried the enzymatic ability to reverse the flow of information from RNA back to DNA using reverse transcriptase. Reverse transcriptase was also independently and simultaneously discovered in association with the murine leukemia virus by David Baltimore at the Massachusetts Institute of Technology.... Both scientists completed their initial work with RNA-dependent DNA polymerase with the Rous sarcoma virus." (Wikipedia article on Howard Martin Temin, accessed 3-2020).

In 1975 Temin shared the Nobel Prize in Physiology or Medicine with David Baltimore and Renato Dulbecco "for their discoveries concerning the interaction between tumour viruses and the genetic material of the cell."

Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Synthesis, NOBEL PRIZES › Nobel Prize in Physiology or Medicine, ONCOLOGY & CANCER, VIROLOGY › Molecular Virology, VIROLOGY › VIRUSES (by Family) › Retroviridae › Rous Sarcoma Virus (RSV)
  • 2660.24

Combination chemotherapy in the treatment of advanced Hodgkin’s disease.

Ann. intern. Med. 73, 881-95, 1970.

Combination chemotherapy with nitrogen mustard (mustine hydrochloride), vincristine sulphate, procarbazine hydrochloride and prednisone, introduced in 1964 for the treatment of advanced Hodgkin’s disease. With A. A. Serpick and P. P. Carbone.

Subjects: ONCOLOGY & CANCER, ONCOLOGY & CANCER › Chemotherapy for Cancer, ONCOLOGY & CANCER › Lymphoma
  • 2660.25

Malignant lymphoma in cottontop marmosets after inoculation with Epstein–Barr virus.

Proc. nat. Acad. Sci. (Wash.), 70, 2487-91, 1973.

Epstein-Barr virus as a cause of Burkitt’s lymphoma. With D. DeChairo and G. Miller.

Subjects: ONCOLOGY & CANCER › Lymphoma, VIROLOGY › VIRUSES (by Family) › Herpesviridae › Epstein-Barr Virus
  • 2660.26

Field trials with an attentuated cell associated vaccine for Marek's disease.

Vet. Rec., 77, 1339-1340, 1970.

In 1959 Biggs moved to the Houghton Poultry Research Station (HPRS) to form and head a unit to study lymphoid tumor conditions of the domestic fowl. He gave the name Marek’s disease to one of the tumor conditions, after the Hungarian veterinarian József Marek. Biggs and his group determined that it was caused by a herpesvirus, and later developed a vaccine for the disease. With six co-authors.

Subjects: IMMUNOLOGY › Vaccines, ONCOLOGY & CANCER, VETERINARY MEDICINE, VIROLOGY › VIRUSES (by Family) › Herpesviridae › Gallid alphaherpesvirus 2
  • 2660.27

From the molecular biology of oncogenic DNA viruses to cancer. Les Prix Nobel en 1975, pp. 172-80.

Stockholm: Nobel Foundation, 1975.

In 1975 Dulbecco shared the Nobel Prize in Physiology or Medicine with David Baltimore and Howard Martin Temin "for their discoveries concerning the interaction between tumour viruses and the genetic material of the cell."

Subjects: BIOLOGY › MOLECULAR BIOLOGY, NOBEL PRIZES › Nobel Prize in Physiology or Medicine, ONCOLOGY & CANCER, VIROLOGY › Molecular Virology
  • 2660.28

DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA.

Nature, 260, 170-73, 1976.

Discovery of the first “oncogene.

In 1989 Varmus and Bishop shared the Nobel Prize for in Physiology or Medicine "for their discovery of the cellular origin of retroviral oncogenes."

  • 2660.3

Contributions to the study of marine products. XXXII. The nucleosides of sponges.

I. J. org. Chem. 16, 981-7, 1951.

Cytosine arabinoside, a pyramidine antagonist, used in acute myeloblastic anemia.

  • 2660.4

Aryl-2-halogenoalkylamines. Part XII. Some carboxylic derivatives of NN-Di 2-chloroethylaniline.

J. chem. Soc. 2386-92, 1953.

Chlorambucil (a nitrogen mustard) used in the chemotherapy of cancer. With J. R. Roberts and W. J. C. Ross.

Subjects: ONCOLOGY & CANCER, ONCOLOGY & CANCER › Chemotherapy for Cancer
  • 2660.5

Clinical studies on the carcinolytic action of triethylenephosphoramide.

Cancer, 6, 135-41, 1953.

TEPA. With five co-authors.

  • 2660.6

The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy.

Brit. J. Radiol., 26, 638-48, 1953.

The sensitivity of tumour cells to x rays shown to be much enhanced when irradiated in a well-oxygenated medium. With A. D. Conger, M. Ebert, S. Hornsey, and O. C. A. Scott.

Subjects: ONCOLOGY & CANCER › Radiation (Radiotherapy)
  • 2660.7

Cytoactive amino-acid and peptide derivatives. I. Substituted phenylalanines.

J. chem. Soc., 2409-17, 1954.

Melphalan (a nitrogen mustard) later used in the chemotherapy of cancer.

Subjects: ONCOLOGY & CANCER, ONCOLOGY & CANCER › Chemotherapy for Cancer
  • 2660.8

Carcinolytic action of antibiotics: puromycin and actinomycin.

D. Amer. J. Path., 31, 582 (only), 1955.

  • 2660.9

Fluorinated pyrimidines, a new class of tumour-inhibitory compounds.

Nature (Lond.), 179, 663-6, 1957.

Synthesis of 5-fluorouracil. With eight co-authors.

  • 2661

Die Carcinomlitteratur. Eine Zusammenstellung der in-und ausländischen Krebsschriften bis 1900.

Berlin: R. Schoetz, 1901.

Subjects: ONCOLOGY & CANCER › History of Oncology & Cancer
  • 2661.1

Die Lehre von der Krebskrankheit von den ältesten Zeiten bis zur Gegenwart. 4 vols.

Jena: Fischer, 19071928.

Exhaustive and accurate review of all the then-available information on cancer. Digital facsimile from Google Books at this link.

English translation of vol. 1 as The science of cancerous disease from the earliest times to the present. With a new introduction by Saul Jarcho. Canton, MNA: Science History Publications, 1989.

Subjects: ONCOLOGY & CANCER › History of Oncology & Cancer
  • 2662

An exhibit of important books, papers, and memorabilia illustrating the evolution of the knowledge of cancer.

Amer. J. Cancer, 18, 42-126, 1933.

Subjects: BIBLIOGRAPHY › Bibliographies of Specific Subjects, ONCOLOGY & CANCER › History of Oncology & Cancer
  • 2662.1

Index to the literature of experimental cancer research 1900-1935.

Lancaster, Pa: Wickersham Printing Co., 1948.

Divided into author and subject sections.

Subjects: BIBLIOGRAPHY › Bibliographies of Specific Subjects, ONCOLOGY & CANCER › History of Oncology & Cancer
  • 2662.2

Bibliographic control of the literature of oncology 1800-1960.

Metuchen, NJ: Scarecrow Press, 1969.

Includes a short, well-documented history.

Subjects: BIBLIOGRAPHY › Bibliographies of Specific Subjects, ONCOLOGY & CANCER › History of Oncology & Cancer
  • 2662.3

Contrary to nature. Being an illustrated commentary on some persons and events of historical importance in the development of knowledge concerning cancer.

Washington, DC: Dept. Health, Education & Welfare, 1977.

Subjects: ONCOLOGY & CANCER › History of Oncology & Cancer
  • 2662.4

The genesis of cancer. A study in the history of ideas.

Baltimore, MD: The Johns Hopkins University Press, 1978.

Subjects: ONCOLOGY & CANCER › History of Oncology & Cancer
  • 2662.5

The theory and practice on oncology. Historical evolution and present principles.

Carnforth, Lancs., England: Parthenon Publishing, 1990.

Subjects: ONCOLOGY & CANCER › History of Oncology & Cancer
  • 2663

Galen on respiration and the arteries. An edition with English translation and commentary of De usu respirationis, An in arteriis natura sanguis contineatur, De usu pulsuum, and De causis respirationis, by David J. Furley and J. S. Wilkie.

Princeton, NJ: Princeton University Press, 1984.

Galen's system of medicine based on the minutiae of pulse variations persisted into the 18th century.

  • 2664

Galen: De differentiis morborum libri ii…

Paris: Officina Henrici Stephani , 1514.

First Renaissance Latin translation by Niccolò Leoniceno of Vicenza of Galen's work on physical diagnosis.

  • 2665

De morborum symptomatis.

London: R. Pynson, 1522.

This volume of Galen’s selected works includes Thomas Linacre’s Latin translation of De symptomatum differentiis.

  • 2666

HOC.IN.VOLVMINE.ACTVARI.GRÆCI auctoris medici praestantissimi digesti sunt de urinis libri septem de græco sermone in latinum conversi: in quibus omnia: que de urinis dici possunt: sive practicam sive Theoricam: sive cognitionem: sive prognostica quæsiveris: doctissime tractata continentur, Unde lector optime: si diligenter his libris infadaveris glumam paucă ex aliorsi lectionet: ex hac ipsa grans multum te colle gisse cognoveris.

Venice: Bernardinus Vitalis, 1519.

The most complete medieval treatise on urinoscopy, translated from the Greek by Ambrogio Leone  (1458/9- 1525) professor of medicine in Naples). Johannes Actuarius, the last of the great Byzantine physicians, was first to use a graduated glass for its examination. Actuarius or Actarius (Greek: ἀκτουάριος), was a title applied to officials of varying functions in the late Roman and Byzantine empires. By 12th century, or perhaps in the 11th century, the term came to be applied to prominent physicians, possibly those attached to the imperial court. By the 16th century the title Actuarius was conflated as Joannes's last name. Digital facsimile of the 1519 edition from Google Books at this link. Partial English translation in No. 2241.

  • 2667

De iis qui morborum simulant deprehendendis liber.

Milan: ex off quondam P. Pontii, 1595.

The first treatise on feigned diseases.

  • 2668

Commentaria in primam fen primi libri canonis Avicennae.

Venice: Jacobus Sarcina, 1625.

The chief value of this work is in its cautious revelation of the principles of construction of various instruments that Santorio had invented, including a hygrometer, a pendulum for measuring pulse rate, a syringe for extracting bladder stones, and a bathing bed. The instruments are depicted in woodcut diagrams, the earliest illustrations of Santorio’s instruments. For the first description of Santorio’s pulse-clock see No. 572.1.

  • 2670

The physician’s pulse-watch. 2 vols.

London: S. Smith & B. Walford, 17071710.

Before watches had hands to record the seconds, Floyer invented a pulse-watch which divided the minute. He was the first to count the pulse with the aid of a watch and to make regular observations on the pulse-rate. The second volume contains the first English translation of Cleyer’s book on Chinese pulse-lore, Specimen medicinae Sinicae. (see No. 6492).

  • 2671

Essays medical and philosophical.

London: A. Millar, 1740.

First important work on clinical thermometry, and the only scientific treatment of the subject before Wunderlich.

Subjects: INSTRUMENTS & TECHNOLOGIES › Medical Instruments › Thermometer
  • 2672

Inventum novum ex percussione thoracis humani ut signo abstrusos interni pectoris morbos detegendi.

Vienna: J. T. Trattner, 1761.

The greatness of Auenbrugger’s discovery of the value of immediate percussion of the chest as a diagnostic measure was not recognized until many years after he first published. His little book met with a cold reception, while a French translation by Rozière de la Chassagne in 1770 attracted little notice. But Auenbrugger lived to see the appearance in 1808 of J. N. Corvisart’s classic translation of the book, after which the value of percussion was universally recognized. It should be noted that recognition did not occur until nearly 50 years after Auenbrugger first published.

English translation by J. Forbes, 1824 (reprinted in Willius and Keys, Cardiac classics, 1941., pp. 193-213); also with introduction by H. E. Sigerist, in Bull. Hist. Med., 1936, 4, 373-403. For bibliography of the Inventum novum see P.J. Bishop, Tubercle, 1961, 42, 78. The facsimile reprint by Max Neuburger (Vienna, 1922) includes a facsimile of the original edition, and translations into English, French and German.

Subjects: PHYSICAL DIAGNOSIS › Percussion
  • 2672.1

Lichtleiter, eine Erfindung zur Anschauung innerer Theile und Krankheiten nebst der Abbildung.

J. pract. Heilk, 24, 1 St., 107-24, 1806.

Bozzini introduced a speculum in which the idea of illumination and reflection by mirrors was utilized. English translation in Urology, 1974, 3, 119-23. Bozzini published his work in book form, Der Lichtleiter, Weimar, 1807, which is translated in Quart. Bull. Northw. Univ. med. Sch., 1949, 23, 332-54.

Subjects: INSTRUMENTS & TECHNOLOGIES › Medical Instruments
  • 2672.2

Séméiologie générale, ou traité des signes et de leur valeur dans les maladies. Vol. 2.

Paris: Croullebois, 1817.

Double introduced and applied auscultation (pp. 31 and 186).

Subjects: PHYSICAL DIAGNOSIS › Auscultation
  • 2673
  • 3219
  • 3614

De l’auscultation médiate, ou traité du diagnostic des maladies des poumons et du coeur. 2 vols.

Paris: J A. Brosson & J. S. Claudé, 1819.

This book revolutionized the study of diseases of the chest. Auscultation in the instrumental sense dates from Laennec’s invention of the stethoscope (at first merely a roll of stiff paper) with a view to amplifying the sound of the heart’s action. The work illustrates Laennec's wooden stethoscope, which could be purchased from the publishers, and which was advertised for sale on the original printed wrappers of the first edition. Laennec's first wooden stethoscope was in two parts; later he invented a three-part stethoscope.

Laennec was considered the greatest teacher of his time on tuberculosis. Indeed, it was in elaboration of his investigation of the disease that he invented the stethoscope. He established the fact that all phthisis is tuberculous, described pneumothorax and distinguished pneumonia from the various kinds of bronchitis and from pleuritis. “Laennec’s cirrhosis” – chronic interstitial hepatitis – is described on p. 368 of Vol. 1. The second edition, 1826, is even more important, since it gives not only the various physical signs elicited in the chest, but adds the pathological anatomy, diagnosis, and treatment of each disease encountered. Laennec died of tuberculosis at the early age of 45. English translation of the first edition by J. Forbes, London, 1821. 

Subjects: HEPATOLOGY › Diseases of the Liver, INFECTIOUS DISEASE › Pneumonia, INSTRUMENTS & TECHNOLOGIES › Medical Instruments › Stethoscope, PHYSICAL DIAGNOSIS › Auscultation, PULMONOLOGY › Lung Diseases › Pulmonary Tuberculosis
  • 2674

An introduction to the use of the stethoscope.

Edinburgh: Maclachlan & Stewart, 1825.

Stokes, famous member of the Irish school of medicine, published the first systematic treatise on the use of the stethoscope – and this before his qualification at Edinburgh. His name is perpetuated in medical literature in connection with “Cheyne–Stokes respiration” and the “Stokes–Adams syndrome.”

Subjects: INSTRUMENTS & TECHNOLOGIES › Medical Instruments › Stethoscope, PHYSICAL DIAGNOSIS › Auscultation
  • 2675

De la percussion médiate.

Paris: J. S. Chaudé, 1828.

Piorry, pioneer of mediate percussion, introduced the percussor and the pleximeter in 1826. He also developed refinements to Laennec’s stethoscope.

Subjects: INSTRUMENTS & TECHNOLOGIES › Medical Instruments › Stethoscope, PHYSICAL DIAGNOSIS › Auscultation, PHYSICAL DIAGNOSIS › Percussion
  • 2676

Abhandlung über Perkussion und Auskultation.

Vienna: Witwe & Braumüller, 1839.

Skoda classified the various sounds obtained on percussion according to their musical pitch and tone. “Skoda’s resonance” is an important diagnostic sign in pneumonia and pericardial effusion. Following Skoda’s work, percussion at last gained general acceptance as a diagnostic procedure. Digital facsimile of the 1842 second edition from the Internet Archive at this link. English translation, 1853.

Subjects: INFECTIOUS DISEASE › Pneumonia, INSTRUMENTS & TECHNOLOGIES › Medical Instruments › Stethoscope, PHYSICAL DIAGNOSIS › Auscultation, PHYSICAL DIAGNOSIS › Percussion
  • 2676.1

On the self-adjusting double stethoscope.

Lancet, 2, 138, 202, 1856.

Leared demonstrated a binaural stethoscope at the Great Exhibition, London, 1851. Camman introduced the pattern whose main design continues in use today; this was illustrated in the N.Y. med. Times, Jan. 1855, and reproduced in Lancet, 1856, 1, 398.

Subjects: INSTRUMENTS & TECHNOLOGIES › Medical Instruments, INSTRUMENTS & TECHNOLOGIES › Medical Instruments › Stethoscope, PHYSICAL DIAGNOSIS › Auscultation
  • 2676.2

Ueber dasverschiedene Verhalten gelähmter Muskeln gegen den constanten und inducirten Strom und die Erklärung desselben.

Dtsch. Klinik, 16, 65-69, 1864.

One of the first publications on electrodiagnosis.

  • 2677

Das Verhalten der Eigenwärme in Krankheiten.

Leipzig: O. Wigand, 1868.

This work on temperature in disease laid the foundation of modern knowledge regarding clinical thermometry. Wunderlich reportedly took over a million measurements from 25,000 people. Temperatures ranged from 97.2 to 99.5, and the mean normal human body temperature was 98.6. Wunderlich also established 100.4 degrees as “probably febrile.” Garrison said of Wunderlich that he “found fever a disease and left it a symptom.” The New Sydenham Society published an English translation, On the temperature in diseases: A manual of medical mhermometry, in 1871.

Subjects: INSTRUMENTS & TECHNOLOGIES › Medical Instruments › Thermometer, PHYSICAL DIAGNOSIS
  • 2678

On markings of furrows on the nails as the result of illness.

Lancet, 1, 5-6, 1869.

  • 2679

Medical thermometry.

Brit for med.- chir. Rev., 45, 429-41, 1870.

Allbutt introduced the modern clinical thermometer.

Subjects: INSTRUMENTS & TECHNOLOGIES › Medical Instruments, INSTRUMENTS & TECHNOLOGIES › Medical Instruments › Thermometer, PHYSICAL DIAGNOSIS
  • 2680

The pulse.

London: Cassell & Co., 1890.

  • 2680.01
  • 5622.1

The mechanics of surgery.

Chicago, IL: Charles Truax & Co., 1899.

An encyclopedic work that described illustrated and analysed the entire range of instrumentation employed in medical and surgical practice at the end of the 19th century. Reprinted with introduction by James M. Edmonson: San Francisco, Norman Publishing, 1988.

Subjects: INSTRUMENTS & TECHNOLOGIES › Medical Instruments, INSTRUMENTS & TECHNOLOGIES › Surgical Instruments, SURGERY: General
  • 2680.1

Ultrasonic visualization of soft-tissue structures of the body.

J. Lab. clin. Med., 40, 579-92, 1952.

First tomogram of soft tissue.

Subjects: IMAGING › Sonography (Ultrasound), INSTRUMENTS & TECHNOLOGIES
  • 2681

Progress in the techniques of soft tissue examination by 15 MC pulsed ultrasound. In: Ultrasound in biology and medicine, ed. E. Kelly, pp. 30-48.

Washington, DC: American Institute of Biological Sciences, 1957.

Subjects: IMAGING › Sonography (Ultrasound)
  • 2682

Investigation of abdominal masses by pulsed ultrasound.

Lancet, 1, 1188-94, 1958.

Donald, J. MacVicar and T. G. Brown used an ultrasound scanner to investigate the pregnant abdomen (see also No. 6235.1).

Subjects: IMAGING › Sonography (Ultrasound), OBSTETRICS & GYNECOLOGY › OBSTETRICS
  • 2682.5

The early history of instrumental precision in medicine.

New Haven, CT: Tuttle, Moorehouse & Taylor, 1892.

Subjects: INSTRUMENTS & TECHNOLOGIES › History of Biomedical Instrumentation
  • 2682.51

The history of the forceps: An investigation on the occurrence, evolution, and use of the forceps from prehistoric times to the present (with a summary in Danish). Translated by William Ernest Calvert.

Oxford: Oxford University Press, 1938.

Not limited to the obstetric forceps.

Subjects: INSTRUMENTS & TECHNOLOGIES › History of Biomedical Instrumentation, INSTRUMENTS & TECHNOLOGIES › Medical Instruments › Forceps, OBSTETRICS & GYNECOLOGY › OBSTETRICS › History of Obstetrics
  • 2682.52

Medicine and the reign of technology.

Cambridge & New York: Cambridge University Press, 1978.

Subjects: INSTRUMENTS & TECHNOLOGIES › History of Biomedical Instrumentation
  • 2682.53
  • 5813.12

Antique medical instruments

Berkeley, CA: University of California Press & London: Sotheby Parke Bernet, 1979.

Well-illustrated work coving the history of medical and surgical instruments from the Middle Ages to 1870, with emphasis on pre-19th century material. Includes useful information on instrument makers.

Subjects: INSTRUMENTS & TECHNOLOGIES › History of Biomedical Instrumentation
  • 2682.54

Bloodletting instruments in the National Museum of History and Technology.

Washington, DC: Smithsonian Institution Press, 1979.

Digital facsimile from Smithsonian Research Online at this link.

Subjects: INSTRUMENTS & TECHNOLOGIES › History of Biomedical Instrumentation, THERAPEUTICS › Bloodletting
  • 2682.55

Medicine and its technology: an introduction to the history of medical instrumentation.

Westwood, CT: Greenwood Press, 1981.

Subjects: INSTRUMENTS & TECHNOLOGIES › History of Biomedical Instrumentation
  • 2682.56

Encyclopedia of medical devices and instrumentation. 4 vols

New York: John Wiley & Sons, 1988.

Some of the articles in this work include historical references, useful for the recent history of this rapidly evolving field.

Subjects: Encyclopedias, INSTRUMENTS & TECHNOLOGIES, INSTRUMENTS & TECHNOLOGIES › History of Biomedical Instrumentation
  • 2683

Ueber eine neue Art von Strahlen. (Vorläufige Mittheilung.); Eine neue Art von Strahlen. II. Mittheilung.

Sitzber. phys. -med. Ges. Würzburg, 132-41; Ibid, 11-16, 16-19, 1895, 1896.

The discovery of x rays, which Kölliker later renamed “Roentgen rays”; the foundation stone of the science of roentgenology. English translation in Nature, (February,) 1896, 53, 274 and 377. See also Röntgen’s third paper on the subject: Weitere Beobachtungen über die Eigenschaften der X-Strahlen. Sitzber. K. Preuss. Akad. Wiss., Ber., Kl. Phys.-Math., 1897, 576-592. Facsimile reprint of all three papers, English translation, and bibliography in H. Klickstein, Wilhelm Conrad Röntgen on a new kind of rays. A bibliographical study, 2 vols., 1966.

In 1901 Röntgen was awarded the first Nobel Prize in Physics "in recognition of the extraordinary services he has rendered by the discovery of the remarkable rays subsequently named after him."

Subjects: IMAGING › X-ray, NOBEL PRIZES, NOBEL PRIZES › Nobel Prize in Physics, RADIOLOGY
  • 2684

The discovery of a bullet lost in the wrist by means of the Roentgen rays.

Lancet, 1, 476-77, 1896.

This was probably the first published report of the clinical use of x rays (February 22).

Subjects: IMAGING › X-ray, RADIOLOGY
  • 2684.1

The clinical application of the roentgen rays in surgical diagnosis.

Am. J. med. Sci. 111, 256-61, 1896.

First clinical application in America, published in March, 1896.

  • 2001
  • 2684.2

Sur les radiations émises par phosphorescence.

C. R. Acad. Sci. (Paris), 122, 420-21, 1896.

The discovery of radioactivity – research stimulated by Roentgen’s discovery of x rays. 

In 1903 Becquerel received half of the Nobel Prize in Physics 1903 "in recognition of the extraordinary services he has rendered by his discovery of spontaneous radioactivity." The half was awarded to Pierre Curie and Marie Curie, née Skłodowska "in recognition of the extraordinary services they have rendered by their joint researches on the radiation phenomena discovered by Professor Henri Becquerel."

Subjects: NOBEL PRIZES › Nobel Prize in Physics, ONCOLOGY & CANCER › Radiation (Radiotherapy), RADIOLOGY, Radiation Oncology
  • 2684.3
  • 3689

The x-ray and its application to dentistry.

Dental Cosmos, 38, 478-86, 1896.

First dental radiography in America.

  • 2685

A few remarks on experiments with Roentgen rays.

Electricity, New York, 10, 68-69, 1896.

Introduction of the intensifying screen.

  • 2686

Stereoscopic Roentgen pictures.

Electrical World, New York, 27, 280, 1896.

Invention of the Roentgen stereoscope.

Subjects: IMAGING › X-ray, RADIOLOGY
  • 2686.1

A method for more fully determining the outline of the heart by means of the fluorescope together with other uses of this instrument in medicine.

Boston med. surg. J. 135, 335-337, 1896.

Estimation of heart size by fluoroscope, first application of x rays to cardiology.

  • 2687

X-ray records for the cinematograph.

Arch. Skiagraphy, 1, 37, 1897.

Macintyre was the first to demonstrate x-ray cinematography.

Subjects: IMAGING › X-ray
  • 2687.1
  • 3519

The movements of the stomach studied by means of the Roentgen rays.

Amer. J. Physiol., 1, 359-82, 1898.

Cannon introduced the bismuth meal. He showed that bismuth, opaque to x rays, could be of great use in conjunction with roentgenology in the investigation of the digestive tract. See No. 1029.

  • 2687.2

The use of the Röntgen ray by the Medical Department of the United States Army in the war with Spain (1898).

Washington, DC: Government Printing Office, 1900.

The Spanish-American War was the first war in which X rays were used for diagnostic purposes. This is the first report on the application of X rays in military medicine. Digital facsimile from the Internet Archive at this link.

  • 2687.3

The Roentgen rays in medicine and surgery.

New York: Macmillan, 1901.

Because of rapid developments in this field Williams put this book through three editions, in 1901, 1902, and 1903. Digital facsimile of the 1901 first edition from the Wellcome Collection at this link, of the 1902 second edition from the Internet Archive at this link, and of the 1903 third edition from the Wellcome Collection at this link.

  • 2688

Eine neue, einfache Dosirungsmethode in der Radiotherapie (das Chromoradiometer).

Wien. Hin. Rdsch., 16, 685-87, 1902.

Holzknecht did important work on x-ray dosimetry.

  • 2689

Die Röntgen-Technik.

Hamburg: L. Gräfe & Sillem, 1903.

Albers-Schönberg invented the compression diaphragm, the function of which is to intensify the object by cutting out secondary rays.

  • 2690

Die Technik der Roentgenkinematographie.

Dtsch. med. Wschr. 35, 434-35, 1909.

Groedel invented the first machine for taking serial x-rays.

Subjects: IMAGING › X-ray
  • 2691

A grafting-diaphragm to cut off secondary rays from the object.

Arch. Roentgen Ray, 18, 6-9, 19131914.

Bucky devised a diaphragm for roentgenography which, by preventing the secondary rays from reaching the plate, secured better contrast and definition.

  • 2692

A powerful Roentgen ray tube with a pure electron discharge.

Amer J. Roentgenol, n.s. 1, 115-24, 19131914.

Coolidge invented the high vacuum tube, capable of kilovoltage energies.

  • 2692.1

Diaphragming Roentgen rays. Studies and experiments.

Amer. J. Roentgenol. 3, 142-5, 1916.

Moving grid. "Bucky-Potter grid" invented by Gustav Bucky and improved by radiologist Hollis E. Potter.

  • 2692.2

Aqueous solutions of potassium and sodium iodids as opaque mediums in roentgenography.

J. Amer. med. Assoc. 70, 754-5, 1918.

  • 2693
  • 4605

Méthode radiographique d’exploration de la cavité épidurale par la lipiodol.

Rev. neurol. (Paris), 28, 1264-66, 1921.

Positive contrast myelography with iodized oil (lipiodol). This paper records the first use of lipiodol in radiology.

Subjects: IMAGING › X-ray, NEUROLOGY › Diseases of the Nervous System, RADIOLOGY
  • 2694

Einstellung der Röntgenologie.

Vienna: Julius Springer, 1927.

  • 2695

Eine neue Methode zur röntgenologischen Darstellung der Milz.

Fortschr. Röntgenstr. 40, 497-501, 1929.

Thorium dioxide (“thorotrast”) first used in radiological diagnosis.

  • 2696

Archiv und Atlas der normalen und pathologischen Anatomie in typischen Röntgenbildern. Das röntgenographische Bewegungsbild und seine Anwendung (Flachenkymographie und Kymoskopie).

Fortschr. Röntgenstr, 1931.

Introduction of roentgen kymography.

  • 2697

Roentgen ray motion pictures of the stomach.

Proc. Mayo Clin., 7, 669- 71, 1932.

Camera used for direct Roentgen-cinematography.

  • 2698


Forschr. Röntgenstr. 47, 399-407, 1933.

Tomography first described.

  • 2699


Fortschr. Röntgenstr. 51, 61-80, 191-208, 1935.

Grossmann's tomograph was able to image a single slice through the body. He was influential in establishing the word "tomographie" in its radiological context.